5 Essential Elements For methadone maintenance treatment
[sixty one] Like many other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, that is much less powerful as an opioid, is much more potent at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone provides a lower affinity, with an IC50